Ghostbusters

Jared and Jensen wear Ghostbusters inspired jumpsuits

Jensen with the Ectomobile/Ecto-1 from Ghostbusters at Sony Studios in 2014

Ghostbusters is a 1984 comedy about a group of friends who catch supernatural entities, it spawned a film franchise.

Ghostfacers

The Ghostfacers are a team of ghost hunters first appearing in 3.13 Ghostfacers. The Ghostfacers are founded by Ed Zeddmore and Harry Spengler who first appeared in 1.17 Hell House as the founders of the website Hell Hound's Lair. They are inspired by the Ghosbusters team as the names Ed Zeddmore and Harry Spengler are a reference to the characters Winston Zeddmore and Egon Spengler from the original Ghostbusters movie. Later on, other members join the team: Maggie Zeddmore, Spruce, Alan J. Corbett, Ambyr and Dave.

• They have their own Tie-in comic: The Beast with Two Backs penned by Eric Kripke with Peter Johnston and published in 2008.
• They have their own spin-off series: the Ghostfacers Web Series, an 11 episodes web series airing in 2010.

Episodes

1.07 Hook Man

Dean: Nice job, Dr. Venkman.

Dr. Peter Venkman is the character played by Bill Murray in the Ghostbusters film series.

1.17 Hell House

Ed Zeddmore and Harry Spengler's names , are a references to the characters Winston Zeddmore and Egon Spengler from the original Ghostbusters movie.

Dean: Who ya gonna call!

Dean's shout of "Who ya gonna call?" is a popular quote from the same movie. Ed and Harry later form the Ghostfacers.

2.16 Roadkill

Molly: So this is really what you guys do? You're like Ghostbusters?

3.13 Ghostfacers

The Ghostfacers are featured in this episode.

The Ghostfacers theme song is very reminiscent of the Ghostbusters theme, also having a line about "who you're going to call." Furthermore, the Ghostfacers have a huddle cheer similar to the one used by the Ghostbusters.

3.16 No Rest for the Wicked

Dean: Well, this is a terrific plan. I'm excited to be a part of it. Can we go, please?

This line is almost a direct quote from the movie Ghostbusters. Bill Murray uses this line right before the Ghostbusters take out Gozer by crossing the streams.

4.17 It's a Terrible Life

The Ghostfacers are featured in this episode.

5.09 The Real Ghostbusters

The title of the episode refers to a 1980s animated TV show based on the movie Ghostbusters.

8.16 Remember the Titans

Hayley: Okay, so Ollie's dad is a Greek God who has been cursed to die every day by Zeus. And you guys are... Ghostbusters. Am I getting this right?

8.18 Freaks and Geeks

Dean: Sheriff, why do you think we're here? You just crossed streams with a federal investigation.

To 'cross the streams' is a phrase from the Ghostbusters movie franchise. It refers to when two or more Proton Streams cross paths.

9.15 #thinman

The Ghostfacers are featured in this episode.

10.05 Fan Fiction

Dean: We came, we saw, we kicked its...

This is a quote from the movie Ghostbusters.

Everyone: Ghooooost-facerssss !

The teen actresses do the Ghostfacers', Ghostbuster inspired huddle cheer.

10.13 Halt & Catch Fire

Delilah: So you're like Ghostbusters?
Dean: Sure.

11.02 Form and Void

Barb: Well, who are we gonna call?

Dean: Ghostbusters. Jenna, hey. Whoa, whoa, whoa, slow down. What's wrong?

"Who ya gonna call?" is the catchphrase from the movie Ghostbusters.

11.05 Thin Lizzie

The Ghostfacers are mentioned in this episode.

12.15 Somewhere Between Heaven and Hell

Sam: Mom just finished working a haunting in Akron.

Dean: The Brits?
Sam: Yeah.
Dean: Great. Who you gonna call? Douchebusters.

"Douchebusters" is a reference/play on Ghostbusters, with "Who you gonna call?" being the franchise's tag line.

13.17 The Thing

Dean: Okay, look, I don't know what kind of kinky Gatekeeper-Keymaster thing you got going on here, but... I think I'll pass.

"Gatekeeper-Keymaster" refers to the original Ghostbusters movie in which Dana (Sigourney Weaver) is possessed by the demigod Zuul, the "Gatekeeper" and her neighbor Louis (Rick Moranis) by Vinz Clortho who is the "Keymaster". A sexual ritual between them will open a gateway to allow The Destructor entry into that world. In Cthulhu Mythos, the entity Yog-Sothoth is sometimes referred to as "The Key and the Gate." In Lovecraft's short story "The Dunwich Horror", Yog-Sothoth impregnates a mortal woman, Lavinia Whateley.

14.20 Moriah

The climactic ending where the souls emerge from Hell and resume terrorizing people is reminiscent of the climactic scene from Ghostbusters where the Ecto Containment System is deactivated under the orders of EPA lawyer Walter Peck and the ghosts emerge from the Ghostbusters' headquarters to terrorize New York City.

14.16 Don't Go in the Woods

The Ghostfacers are featured in this episode.

Hillywood Supernatural Parody 2

In the Hillywood Supernatural Parody 2 by The Hillywood Show there are many Ghostbusters references. Most notably Jared Padalecki and Jensen Ackles wear Ghostbusters inspired jumpsuits for a quick cameo.