|Dates||???? – 2011 (killed by Rose Brown)|
|Location||Passaic, New Jersey|
|Episode(s)||6.14 Mannequin 3: The Reckoning|
Isabel was Rose Brown's sister. When she was 16, she had one of Rose's kidneys transplanted into her. She worked at Salzman & Sons Apparel factory.
As a result of giving her sister one of her kidneys, Rose's vengeful spirit can move around, able to go wherever Isabel does. As Sam and Dean try to figure out a way to put Rose's spirit to rest, Rose possesses the Impala and tries to run Dean over. He manages to maneuver it into a wall, but Isabel is fatally injured in the resulting crash. As she dies, the spirit of Rose appears and apologizes before disappearing in flames.