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M2 is a term used to refer to Misha Collins and Mark Pellegrino. It can simply be used as a shorthand term for the actors, or specifically in real person slash to indicate the pairing Misha Collins/Mark Pellegrino. The shorthand came into use following the Asylum Europe: No Rest for the Wicked 2010 convention at which the two actors shared a panel to great success.

Editor: Jumping in to say that the only time I've ever heard the designation M2 it has been in regards to Misha Collins and Mark Sheppard.

See also: Marksha

More information: Real Person Slash