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In [[2.06 No Exit]], H.H. Holmes is haunting the apartment building which was erected over the site where he was hung. In a similar arrangement to the infamous [[Holmes Murder Castle]] in Chicago, he is trapping women in a hidden room. Jo is captured by him, and Sam and
Dena find a way to access the room via the sewers, and rescue Jo, and another kidnapped girl Teresa Ellis.
Jo then acts as bait, and they trap H.H. Holmes inside a ring of salt. Dean then "borrows" a cement truck and they seal the room forever.