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Although [[Uriel]] stated that the only thing capable of killing an [[angel]] is another angel, it seems that the blades are still effective in the hands of a human or [[demon]]. [[Castiel]] gives his blade to the Winchesters to use on [[Anna]],<ref name="five13">[[5.13 The Song Remains the Same]]</ref> and [[Dean Winchester]] kills [[Zachariah]] with one as well<ref name="five18">[[5.18 Point of No Return]]</ref> and later another angel to save [[Ezekiel]].<ref>[[9.01 I Think I'm Gonna Like It Here]]</ref> [[Sam]] is later able to use Castiel's blade to kill two [[demon]]s.<ref name="eight10">[[8.10 Torn and Frayed]]</ref> During an angelic fight, Rachel manages to pierce Castiel in the chest with her blade, but he survives, and he kills her. [[Meg]] is later able to use one to kill [[hellhound]]s, [[Hester]] and a demon.
It may be that the higher the rank of an [[angel]], the more powerful the blade he carries. [[Kali]] refers to [[Gabriel]]'s blade as "an [[archangel]]'s blade." Gabriel's blade was capable of killing archangels, including himself. When an [[angel]] is killed by this weapon, they explode with an intense white light and their wings and halo are burned like ash onto the ground where their body lies. Archangels may only be vulnerable to [[Archangel Blade|archangel blades]], and are immune to regular angel blades because the Winchesters never attempt to kill [[Lucifer]] with an angel blade. However, [[Dean]] and [[Bobby]] attempt to kill [[Raphael]] with an [[angel]] blade in [[6.22 The Man Who Knew Too Much]], which fails when he grabs it before it hits anything. After [[6.22 The Man Who Knew Too Much]] the angelic blade is ineffective against [[Castiel]] after he becomes the new [[God]].
In [[8.07 A Little Slice of Kevin]], Castiel pulls his blade on [[Crowley]], indicating that these blades are effective against demons as well as angels. Crowley dismisses the threat, but Castiel later confirms it in [[8.10 Torn and Frayed]] and it is seen when [[Sam]] kills two [[demon]]s with one. In [[8.19 Taxi Driver]], it is shown that an angel blade can kill a [[reaper]], as demonstrated when [[Crowley]] kills the rogue reaper [[Ajay]] with one of his angel blades. In [[8.21 The Great Escapist]], Crowley has a blade melted-down into bullets for [[Crowley's Gun|a gun]]. As long as the wound is fatal, the bullets work just as well as the blade itself. Angel blades have been shown to be able to kill [[Nephilim]] in [[8.22 Clip Show]] and [[hellhounds]] in [[6.10 Caged Heat]].
In [[12.23 All Along the Watchtower]], Castiel's attempt to kill Lucifer with a standard angel blade showed that archangels can only be killed with [[archangel blade]]sblades.
==Episodes==
As the [[demon]] Sierra attacks Dean, Sam stabs him through the heart from behind with an angel blade, killing Sierra.
In the hallway outside, the Winchesters find the demon Harrington about to kill attacking the [[prophet]] [[Donatello Redfield]]. Unable to reach Harrington in time, Dean flings his angel blade at Harrington like a throwing knife, impaling him through the neck and killing Harrington. Dean's move of throwing the angel blade in such a manner is shown to deeply impress Sam and Donatello.
==Trivia==