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Borax, or sodium borate, is a compound found in most cleaning supplies and is a salt of boric acid. Its use as a weapon against the [[Leviathans]] came by happenstance when [[Sheriff Jody Mills]] spilled a bucket containing the cleaning solution -- Power Clean -- which dripped through the
floor boards of [[Rufus's Cabin]] onto the Leviathan [[Chet]], causing an acidic reaction in his body. The effect is only temporary, but it can allow time to get close enough to decapitate the Leviathan. While weaker Leviathans appear to take longer to heal, the Leviathan leader, [[Dick Roman]], showed higher resistance to borax, healing his burns near instantaneously after exposure and treating it as more of a nuisance than hindrance.
[[File:ChetBorax.jpg|thumb|right|350px|[[Chet]]'s body after prolonged exposure to borax.]]
===[[7.06 Slash Fiction]]===
As [[Bobby]] is testing out various methods to kill the [[Leviathan]] [[Chet]], frustrated that nothing appears to work, Chet begins mocking Bobby by telling him how he plans on eating him. As Bobby raises his machete to strike, several drops of a liquid fall from the ceiling onto Chet's arm and burn his skin, causing Chet to panic and plead for Bobby to get it off of him. The skin on Chet's arm turns yellow, then black, and black steam rises. Another drop falls and Chet's arm continues to burn, causing more pain. Another drop falls onto Chet's face and a large patch on his arm is black, at which point Bobby decapitates Chet once more. Bobby rushes upstairs to find the cause of the acidic effect on Chet, to find [[Jody Mills]], who had been scrubbing the floor and knocked over a bucket containing borax in the cleaning solution. With this information, Bobby places a call to [[Dean]] and instructs him to use anything with sodium borate -- any soaps or laundry powder with "borax" on the label.
Dean has [[Sheriff Osborne]] locate cleaning supplies with borax. In a fight with [[Leviathan!Sam]], Sheriff Osborne throws a bucket of borax onto the Leviathan, allowing Dean to decapitate it with a fire ax. Dean and the sheriff then rush to the interrogation room, where [[Leviathan!Dean]] is preparing to eat [[Sam]]. Dean bursts into the room,
flings liquid at the Leviathan, and cuts off his head with the ax.
===[[7.09 How to Win Friends and Influence Monsters]]===
When [[Charlie Bradbury]] is given [[Frank Devereaux]]'s hard drive to hack, she finds a file on Leviathans and learns what borax will do to them. After witnessing the Leviathan [[Tarrell]] shapeshift and eat her superior, [[Pete]], Charlie flees to her apartment where she is met by Sam and Dean. To prove to her that they are not Leviathans, they pour borax onto their arms, assuaging Charlie's fear when they do not begin to burn. Dean, in turn, pours borax on Charlie's hand to prove that she is human.
[[File:LeviBorax2.jpg|thumb|right|350px|Effects of the borax bomb on a [[Leviathan]].]]
Learning that Dick is having a package delivered from a excavation site in Iran and will have 42 minutes to intercept the package at the airport, Sam, Dean, and Charlie formulate a plan. They successfully switch out the briefcase with one containing a bottle of Power Clean rigged with explosives, creating a borax bomb. When Dick receives the briefcase and opens it, his look of self-satisfaction quickly turns to confusion as the borax bomb counts down and explodes. The explosion causes the lower portion of [Victor!Leviathan|Victor]]'s face to melt, leaving him lying prone on the floor. Dick casually walks over him, with burns on his face, and orders the building locked down. With Charlie trapped in the building Pete begins stomping towards her, but he is knocked down by Bobby who inadvertently sends him into Charlie, breaking her arm. Sam and Dean proceed to crash through the glass doors, and upon Charlie telling them Pete is a Leviathan, Dean throws a jar of borax into his face, causing him to collapse in pain.
===[[7.22 There Will Be Blood]]===
While trying to get the blood of the [[Alpha Vampire]] for their weapon against Dick, Sam and Dean attempt to persuade the Alpha Vampire that the Leviathans are the ones poisoning the vampires. When Edgar arrives, Dean tells the Alpha Vampire that they will need soap or cleansers, anything with borax in it, only to have the Alpha Vampire order his children to lock Sam and Dean up in his study.
While speaking with Edgar, the Alpha Vampire questions him about the side effects of the Leviathan additive, which Edgar answers with indifference, telling him he wants the Alpha and his children to burn. He reveals that the additive kills [[werewolves]], [[shapeshifters]], anything with a taste for human flesh. Angry, the Alpha Vampire tells Edgar "they" come from "them" and that he is a son of Eve, all of which Edgar belittles, saying that the other monsters are nothing but mutts and that Eve was a whore. Edgar's insult to his mother provokes the Alpha to bare his fangs and lunge at Edgar, sending him into the wall. Grabbing a chilled bucket from the table, he splashes it onto Edgar, causing his flesh to burn from the borax. The effects are short, however, as Edgar is able to straighten up and attack the Alpha Vampire. As Edgar's face transforms, he is quickly decapitated by Sam.
===[[7.23 Survival of the Fittest]]===