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→Suitability of a Vessel
The suitability of a human to be a vessel is innate. [[Castiel]] makes reference to this while possessing [[Claire Novak]], saying that it is "in her blood." It appears that [[angel]]s are tied to certain human family lineages. [[Michael]], when he is using the young [[John Winchester]] as his vessel, tells [[Dean Winchester|Dean]]: “You’re my true vessel, but not my only one. It’s a bloodline... stretching back to [[Cain|Cain and Abel]]. It’s in your blood, your father’s blood, your family's blood,”<ref name="five13">[[5.13 The Song Remains the Same]]</ref> with this statement being reinforced by Michael's later use of [[Adam Milligan]], John's son and Dean's half-brother, when Dean refuses to consent to Michael.
Not all vessels are as suitable or durable as others. When unable to secure [[Sam Winchester]] as his vessel after his release, [[Lucifer]] is able to use a a man named [[Nick]] as a substitute, but Nick's body is clearly shown to be decaying as time goes on, requiring him to consume gallons of demon blood to sustain him. After the angels are expelled from [[Heaven]] by [[Metatron]] and fall to Earth, some angels become so desperate for vessels that they take the first available option as hosts, some of which resulted in the host exploding upon possession.<refname="nine03">[[9.03 I'm No Angel]]</ref> The angel [[Hael]] was so desperate to find a suitable vessel that her first host began to decay while she was still inside it, Hael later attempting to force Castiel to consent to possession after the loss of his [[grace]] and subsequent humanity made him a possible vessel.<ref name="nine01" />
Sex appears to be irrelevant for angels as [[Castiel]], [[Hannah]] and [[Raphael]] have all used both male and female vessels. While angels do refer to each other with gendered terms such as "brother" and "sister" when interacting in vessels, it is unclear if angels have any concept of gender as humans would understand it in their natural state, and what influences their choice of vessel.
