[[Crowley]], too, has always avoided being stabbed with the knife.<ref name="five20">[[5.20 The Devil You Know]]</ref><ref name="six10">[[6.10 Caged Heat]]</ref> While Crowley stated that the knife couldn't kill him <ref name="ten22">[[10.22 The Prisoner]]</ref>, this may have been a bluff as he was later shown to be nervous in its presence when Dean pulled it on him after disabling him with an [[angel blade]].<ref name="eleven02">[[11.02 Form and Void]]</ref> Dean was later able to disable Crowley for a time by impaling the knife through his hand,<ref name="twelve23">[[12.23 All Along the Watchtower]]</ref> but Crowley eventually escaped somehow like he'd escaped a similar injury from an angel blade.<ref name="eleven02" /> After freeing himself, Crowley apparently retained the hand wound as he kept the hand that was stabbed wrapped up in a bandage.<ref name="twelve23" />
When [[Abaddon]] was stabbed by the blade, she survives despite experiencing intense pain, revealing that the [[Knights of Hell]] are partially immune to its demon killing abilities.<ref name="eight12"
>[[8.12 As Time Goes By]]</ ref> Unlike Abaddon, [[Cain]] stabs himself with the blade after Dean threatens him and suffers no pain or even any sign of exsanguination.<ref name="nine11" >[[9.11 First Born]]</ ref>
After surviving a killing blow from the knife by Sam, it was revealed that [[Ramiel]] and all [[Princes of Hell]] are immune to the knife's power.<ref name="twelve12"
>[[12.12 Stuck in the Middle (With You)]]</ ref>