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* [[Holy Oil|Holy fire]] - While generally not capable of killing a demon, it will cause them great pain as shown when [[Meg]] was tossed into a ring of it by [[Castiel]] to act as a bridge out<ref name="five10" /> and when Sam doused [[Abaddon]] in it, causing her so much pain she fled her [[meatsuit]].<ref name="eight23" /> However, another demon was able to commit suicide by purposefully dousing himself in holy fire.<ref name="ten03" />
* [[Holy water]] - While most have some vulnerability to holy water, higher-level demons such as [[Lilith]] and [[Azazel]] appear immune.
* [[Iron]] - Demons cannot cross an iron line, and can be hurt with any object made of iron. However, a horde of 100's of demons released from the [[Devil's Gate in Wyoming]], were able to break through the iron railroad devil's trap that surrounded [[Fossil Butte Cemetery]].
* [[Palo Santo]] - Burns in a similar way to holy water, and can kill demons if staked in a fatal area.
* [[Salt]] - Most demons cannot cross a line of salt and they feel intense pain when they come in contact with it. [[Hunters]] use rock salt in shotgun shells to wound and temporarily hinder demons.