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* [[Death]] - It appears only [[Death's Scythe]] is capable of killing Death.* [[Archangels]] - – Lucifer is shown to be invulnerable to the Colt, but a head shot disorients him for a few seconds. Since [[Michael]] seems to be more powerful, it stands to reason This suggests that he cannot be harmed by the Colt either. [[Gabriel]] and [[Raphael]] may be vulnerable archangels are immune to the Colt's powers.* [[Four Horsemen of the Apocalypse]]: – [[Famine]], [[Pestilence]] and [[War]] were rendered powerless with the removal of their rings, so would possibly be vulnerable to the Colt. [[Death]] maintains its power even without its ring, and seems to be more powerful than the other Horsemen. Given Death's claim it would eventually reap God, it may be invulnerable to the Coltas it appears only [[Death's Scythe]] is capable of killing Death.
Lucifer was the only archangel shot, there's nothing to suggest that Gabriel or Raphael could be killed because they are slightly down the totem pole of archangels.
* [[12.18 The Memory Remains]]: Sam uses it to kill the god [[Moloch]].
* [[12.19 The Future]]: Castiel attempted to kill Dagon with the Colt, but she teleported out of the way, while the bullet struck the wall.
===The Five Things the Colt can't kill===
[[Lucifer]] says that there are only five things in all of creation that can't be killed by the Colt and that he is one of them.
There is speculation about what other powerful beings may not be killed by the Colt including:
* [[God]] / [[Chuck]] and [[Amara]] – Given their respective status' as the cosmic embodiment of light and darkness, it is likely they are invulnerable.
* [[Cain]] – When bearing the [[Mark of Cain]], which was given to him by [[Lucifer]], this may have protected him from the Colt. However, he was a [[Knight of Hell]], lower in the hierarchy than the [[Princes of Hell]] who could be killed by the Colt, implying that the Colt can kill Cain.
* [[Eve]] – No clear evidence either way, however as she is dead it is a moot point.
