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Warned by Billie that every version of his fate but one features Michael escaping and destroying the world,<ref name="fourteen10" /> Dean builds the [[Ma'lak Box]], a magical coffin capable of imprisoning even an archangel for eternity,<ref name="fourteen11">[[14.11 Damaged Goods]]</ref> but is talked out of using it and instead trying to find a different option.<ref name="fourteen12">[[14.12 Prophet and Loss]]</ref> After Dean is knocked unconscious by the [[gorgon]] [[Noah Ophis]], Michael escapes his body and takes [[witch]] [[Rowena MacLeod]] as his vessel. However, tapping into the power of his soul, Jack is able to exorcise Michael and burn away the archangel, killing him and allowing Jack to absorb his grace to restore his own Nephilim powers.<ref name="fourteen14" /> However, in the process, Jack burns away his entire [[soul]] and is left [[soulless]] from killing Michael.<ref name="fourteen17">[[14.17 Game Night]]</ref>
Not long after Michael's death, Lucifer's former vessel Nick attempt attempts to resurrect Lucifer from [[the Empty]] with the help of demons.<ref name="fourteen17" /> With Nick's prayer having awakened Lucifer months earlier,<ref name="fourteen07" /> he is able to contact the archangel using [[Prophet]] [[Donatello Redfield]], enhanced by angel grace, as a mouthpiece. Lucifer gives Nick instructions on a ritual involving Jack's blood that will bring Lucifer back from the Empty. Though Nick nearly succeeds, getting as far opening a [[portal]] that Lucifer emerges from, Jack intervenes and banishes Lucifer back to the Empty before killing Nick to keep him from trying again.<ref name="fourteen17" />
When God begins the end of the world, he opens every door in Hell, including the door to Lucifer's Cage. According to the demon [[Belphegor]], the Michael of Sam and Dean's world remains just sitting in the Cage, but Belphegor suggests that he might be looking for revenge for being trapped if he does leave.<ref name="fifteen01">[[15.01 Back and to the Future]]</ref>