After the defeat of Lucifer, Death returns his attention to maintaining the natural order.<ref name="six11">[[6.11 Appointment in Samarra]]</ref> In spite of his own reservations about resurrecting the dead, he retrieves [[Sam]]'s soul from [[Lucifer's Cage]] and returns it to him so that the Winchesters will continue to investigate a greater threat against the balance of life and death.<ref name="six11" />
As a very powerful being that existed before time began, he has extensive knowledge of the universe and is aware of the threats and actions regarding [[Purgatory]]. After [[Castiel]] takes on the role of God, Dean binds Death in hopes he will kill Castiel for them. However, Castiel breaks his binding before he can and leaves. While Death is not happy with their actions, he agrees to help them put the souls back in Purgatory, mostly because he's annoyed with how arrogant Castiel has become.
After the [[Mark of Cain]] causes him to get [[Rudy|another hunter]] killed, Dean summons Death in hopes Death can kill him. However, the Mark's power is such that even Death can't do that and he explains about [[the Darkness]] and the consequences of removing the Mark. He offers to send Dean somewhere far away where he is no threat, but demands Sam's life in exchange. While Dean initially agrees, he instead turns Death's [[Death's Scythe|own scythe]] on him, killing Death who crumbles to dust.
In 2017, it's revealed that the [[reaper]] [[Billie]] has taken Death's place due to a rule stating that the next reaper to die after an incarnation of Death is killed becomes Death themselves. Billie works with the Winchesters from 2019 to 2020 to take down [[God]], but it's revealed that her true plan is to take power as the new God once God and [[the Darkness]] are gone. Mortally wounded by Dean, Billie attempts to kill him as her last act but is absorbed into [[the Empty]] by the [[Cosmic Entity]], whom she had also double-crossed.