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[[Crowley]] approaches Dean and Sam with a job. When Dean is reluctant to listen to him, Crowley reminds him that he owns Sam and can send him back to hell at any time; on the other hand, if they play along and manage to bring him an [[Alpha]], Crowley will give Sam back his soul. Though reluctant to work for Crowley, they don't see any other choice.
He sends Dean and Sam to Buffalo, New York to investigate what appears to be a [[werewolf]] attack. When they arrive, they learn about another attack--so far, both a landlord and a dockworker (Ronald Garrigan) have been found with their chests ripped open and their hearts missing. Sam does some research and discovers what the two men have in common: [[Cal Garrigan]]. If anyone threatens Cal, they end up dead. They follow him and wait for him to turn into a werewolf, but an entire night passes without him changing. Then, when Cal is murdered in the same fashion as the other victims, their next suspect is Cal's girlfriend, [[
Amanda Duren|Mandy]]. Sam is ready to take her in, but Dean is reluctant to capture and take her to Crowley without being sure of her culpability. He goes to see the scene of Cal's murder and do some more research while Sam keeps watch on Cal and Mandy's house. Although Dean doesn't find anything, Sam sees the family dog, [[Lucky]], change into a man, put on clothes, and leave the house.
Sam follows him and sees him talk to another man in a park. When he approaches, though, the man smells him, turns back into Lucky, and tries to run. Before Sam can catch up to him, Lucky is hit by a car and the driver loads him into the back to take him to an animal shelter. Sam, based on information from [[Bobby]], calls Dean and tells him that they are dealing with a [[skinwalker]] posing as a dog.
Sam and Dean take him from the animal shelter, binding him in rope and [[Silver]] chains to restrain him. it transpires that the man was homeless when he was approached and recruited to become a skinwalker by being told that being bitten would make him strong and fast.
[[Lucky]] reveals that there are about
30 Skinwalkers who have been recruited and are living with families as pets. On a signal from their pack leader, they will infect their families, thus recruiting more skinwalkers. He tells Sam and Dean that there are packs in many towns, but he knows nothing of the [[Alpha Skinwalker]]. Lucky leads Sam and Dean to the Pack Leader, but he has kidnapped [[Amanda Duren|Mandy]] and her son and threatens to kill them unless [[Lucky]] turns them. Sam and Dean open fire, and all the Skinwalkers are killed, except Lucky who although shot with a [[Silver]] bullet, escapes. [[Lucky]], in human form, goes to visit [[Amanda Duren|Mandy]] and tells her how he appreciated her kindness, but she tells him to leave. [[Lucky]] transforms into a dog and dejectedly leaves.
* [[Cal Garrigan]]
Amanda Duren]] "Mandy"
At the start of the episode the boys are eating at Fat Mack's BBQ Shack, and at the end they are eating takeout from "Beef Barn".
[[Lucky]] is taken to the Erie County Domestic Animal Hospital}}