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Sam and Dean take [[Lucky]] from the animal shelter and bind him in rope and [[Silver]] chains to restrain him. It transpires that the man was homeless when he was approached and recruited to become a skinwalker--he was told that being bitten would make him strong and fast. Lucky reveals that there are about thirty skinwalkers who have been recruited and are living with families as pets. On a signal from their pack leader, they will infect their families, thus recruiting more skinwalkers. He tells Sam and Dean that there are packs in many other towns, but he knows nothing of the [[Alpha Skinwalker]].
Lucky leads Sam and Dean to the Pack Leader, but he has kidnapped [[Mandy]] and her son, [[Aiden Duran |Aiden]], and threatens to kill them unless [[Lucky]] turns them. Sam and Dean open fire, and all the Skinwalkers are killed except for Lucky, who, although shot with a [[silver]] bullet, escapes.
[[Lucky]], in human form, goes to visit [[Mandy]] and tells her how he appreciated her kindness, but she tells him to leave. [[Lucky]] transforms into a dog and dejectedly leaves.
* [[Cal Garrigan]]
* [[Mandy]]
* [[Aiden Duran]]
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{{TriviaQuote |Text=
Some elements of this episode exhibit a resemblance to Toby Barlow's 2008 epic poem/novel [http://www.harpercollins.com/books/Sharp-Teeth-Toby-Barlow/?isbn=9780061430220 Sharp Teeth].}} {{TriviaQuote |Text=Sam tells Dean that he still likes the same [[Music]] he always has. This is probably a bit of an injoke by the writers as while much is made of Dean's love of classic rock, Sam's musical tastes are a mystery. The only time we get an idea of his musical tastes is in [[4.01 Lazarus Rising]] when Dean is appalled to find an mp3 player in the [[Impala]], which is playing a song by [[jason Jason Manns]]. <br>
At [[Comic Con 2007]], Kripke said Sam listened to "whatever cool modern music is. I don’t know any of them because I don’t listen to anything after 1980..." See [[Music]] for more.