[[Eric Kripke]] said [https://twitter.com/therealKripke/status/664605235814379521 the pilot was inspired by] ''Sandman'', ''Hellblazer'', ''American Gods'', ''Evil Dead'', ''Fletch'', ''Good Omens'' and [https://twitter.com/therealKripke/status/697824345763160064/photo/1 ''The House With A Clock In Its Wall''.]
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Dean uses the line "“shotgun shuts his cakehole” is used rather than the more usual “shotgun shuts his piehole” because [https://twitter.com/therealKripke/status/1468235826995900422 according to Kripke]: "Two reasons. 1) piehole is widely used, I like to mix it up. 2) Dean regards cake dismissively, so it doubles down on the insult."}}
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The pilot was filmed in March/April of 2005 in Los Angeles. The motel scenes were shot at La Crescenta Motel, 2413 Foothill Boulevard, La Crescenta, California, USA. Constance's house was at the Sable Ranch, 25933 Sand Canyon Road, Santa Clarita, California, USA.