Apocalypse

Kansas City

The term "Apocalypse" is commonly and most often used to describe events and disasters that will occur during the end of the world.

Apocalypse in Canon

The Apocalypse or Armageddon is started when The 66 Seals that binds Lucifer to his Cage are broken and he is freed. Zachariah states that when the apocalypse starts Four Horsemen will arise, red oceans and fiery skies will be witnessed^{5.01 Sympathy For The Devil}

The First Seal will break when a righteous Man sheds blood in Hell; Dean Winchester breaks this seal when he spills the blood of a human soul in Hell.
The Last Seal will break when Lilith, the first demon, is destroyed; Sam Winchester breaks this seal when he kills Lilith.

Castiel and Zachariah tell Dean Winchester that he will stop Lucifer. Zachariah later revels that Dean alone cannot possibly kill Lucifer, but he tells Dean that in his occupation as Michael's vessel, he can defeat Lucifer.

Many members of The Host of Heaven like Michael, Raphael and Zachariah wanted The 66 Seals broken so that Lucifer can break free from his Cage, which would give Michael the opportunity to kill him using a vessel, preferably Dean Winchester.

The Four Horsemen of the Apocalypse, the Croatoan Virus and the Whore Of Babylon all served as instruments of destruction during the Apocalypse. Jesse Turner, the Anti-Christ, was also supposed to play an important role during the destruction of Earth, but he decided to turn away from Lucifer's plans.

Following soon after the events of 5.22 Swan Song, a civil conflict in Heaven amongst angels brews. Currently, Raphael is tying to manage Heaven in Michael's absence. He ordered a group of angels to aid him in gathering God's weapons so that he can release Lucifer and Michel, effectively restarting the Apocalypse^{6.03 The Third Man}

The Apocalypse in Fandom

• See Post-Apocalypse fanfic