Dead Man's Blood

The effects of dead man's blood on a vampire.

Dead Man's Blood A poison to vampires that incapacitates them for a short period of time. When the blood from a dead human is injected into a vampire it induces a blood sickness, causing them to become very weak. – Pad of Definitions (1.20 Dead Man's Blood), Official Website

The method of incapacitating a vampire with blood from a dead person is part of vampiric folklore. Tricking a vampire into drinking blood from a dead person to kill him has also been used quite a few times in vampiric tales, notably Interview with the Vampire, wherein the vampire must stop drinking the blood of her/his victim before she/he dies, as drinking blood after death is harmful to the vampire. In Supernatural, dead man's blood has been used as follows:

• John Winchester uses it in 1.20 Dead Man's Blood to restrain Kate, when he uses her as bait to lure out Luther and get the Colt. It's also used to take down Hank with blood-soaked crossbow arrows and later two other vampires who are all killed later.

• Gordon uses it in 2.03 Bloodlust to capture and torture Lenore.

• Dean injects Lucy with dead man's blood to capture her in 3.07 Fresh Blood.

• Samuel Campbell gives Dean a syringe of it when he goes to infiltrate the vampire nest in 6.05 Live Free or Twihard. Samuel describes it as enough dead man's blood to drop a linebacker "and then some." He fails to use it against Boris as a single drop of blood drips from the syringe and he senses it, but during his slaying of all the nest's vampires, Dean injects another vampire with it and presumably later kills him.

• The Alpha Vampire is given an intravenous drip of dead man's blood to restrain him in 6.07 Family Matters, and dead man's blood is spread on the doors of the building in which he is kept as a deterrent to other vampires. Despite the dead man's blood, the Alpha Vampire eventually escapes, though he is weakened and is brought down when the demon possessing Christian Campbell injects him with two syringes at the same time.

• When Sam and Dean decide to go after the Alpha Vampire for his blood in 7.22 There Will Be Blood, they initially decide to go looking for dead man's blood before hitting on the idea of using "vamptonite" from people infected with the Leviathan food-additive.

• When Dean and Benny go after rogue vampire Desmond in 8.09 Citizen Fang, Dean grabs a syringe of dead man's blood from the Impala's trunk which is shown to be stocked with them. In the fight that follows, Desmond overpowers Dean and smashes the syringe, but it distracts him long enough for Benny to kill him.

• In 8.18 Freaks and Geeks, while hunting vampires, Krissy Chambers uses darts filled with dead man's blood to take down Jimmy Day who supposedly killed Josephine Barnes' family, allowing Josephine to kill him. Later, she shoots Seth, the vampire working with Victor Rogers, in the right eye and chest with the darts, taking him down. This saves Aiden whom Seth is holding hostage, and allows the group to get his blood to create the cure for his last victim. The vampire is then presumably killed.

• Dean uses a syringe of dead man's blood on an unnamed vampire son of Celia in 9.19 Alex Annie Alexis Ann and later kills him. A short time later a newly-turned Annie Jones injects Celia with dead man's blood to save Jody Mills. Jody then proceeds to behead Celia.

• When Lady Antonia Bevell is telling Sam how the British Men of Letters protect the country from monsters in 12.01 Keep Calm and Carry On, a vampire entering the UK is shown being injected with dead man's blood and transported for disposal.

• As Dean and Mr. Ketch are preparing to wipe out a vampire nest in Wichita, Kansas, in 12.14 The Raid, Dean grabs a syringe of dead man's blood along with a machete from the Impala trunk.

• Dean injects Officer Doug Stover with dead man's blood in 13.11 Breakdown in order to subdue him until they can cure the man. After being cured, Doug regains consciousness with no ill effects from the dead man's blood.

• An Apocalypse World refugee / hunter gives Mary bullets coated in dead man's blood in 14.01 Stranger in a Strange Land.

• In 14.03 The Scar, a vampire reveals that after being enhanced by Michael, they are now unaffected by dead man's blood. In addition, Jody Mills earlier states that she had Alex Jones test samples from the corpses of what turned out to be vampires with dead man's blood and it had no effect on them.

• In 15.04 Atomic Monsters, when ambushing a vampire suspect, Sam hides a syringe of dead man's blood behind his back. However, they realize the girl is innocent as she has braces on her teeth, which a vampire couldn't have due to their fangs.

• In 15.09 The Trap, in the Butch and Sundance ending, Jody Mills shoots the vampire Sam with a dead man's blood bullet before being killed by Dean. The dead man's blood causes Sam to collapse, allowing Bobby to kill him.