Dead Man's Blood

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The effects of dead man's blood on a vampire.

Dead Man's Blood

A poison to vampires that incapacitates them for a short period of time. When the blood from a dead human is injected into a vampire it induces a blood sickness, causing them to become very weak.

Pad of Definitions (1.20 Dead Man's Blood), Official Website

The method of incapacitating a vampire with blood from a dead person is part of vampiric folklore. Tricking a vampire into drinking blood from a dead person to kill him has also been used quite a few times in vampiric tales, notably Interview with the Vampire, wherein the vampire must stop drinking the blood of her/his victim before she/he dies, as drinking blood after death is harmful to the vampire.


In Supernatural, dead man's blood has been used as follows:

  • Samuel Campbell gives Dean a syringe of it when he goes to infiltrate the vampire nest in 6.05 Live Free or Twihard. Samuel describes it as enough dead man's blood to drop a linebacker "and then some." He fails to use it against Boris as a single drop of blood drips from the syringe and he senses it, but during his slaying of all the nest's vampires, Dean injects another vampire with it and presumably later kills him.
  • The Alpha Vampire is given an intravenous drip of dead man's blood to restrain him in 6.07 Family Matters, and dead man's blood is spread on the doors of the building in which he is kept as a deterrent to other vampires. Despite the dead man's blood, the Alpha Vampire eventually escapes, though he is weakened and is brought down when the demon possessing Christian Campbell injects him with two syringes at the same time.
  • When Dean and Benny go after rogue vampire Desmond in 8.09 Citizen Fang, Dean grabs a syringe of dead man's blood from the Impala's trunk which is shown to be stocked with them. In the fight that follows, Desmond overpowers Dean and smashes the syringe, but it distracts him long enough for Benny to kill him.
  • In 8.18 Freaks and Geeks, while hunting vampires, Krissy Chambers uses darts filled with dead man's blood to take down Jimmy Day who supposedly killed Josephine Barnes' family, allowing Josephine to kill him. Later, she shoots Seth, the vampire working with Victor Rogers, in the right eye and chest with the darts, taking him down. This saves Aiden whom Seth is holding hostage, and allows the group to get his blood to create the cure for his last victim. The vampire is then presumably killed.
  • As Dean and Mr. Ketch are preparing to wipe out a vampire nest in Wichita, Kansas, in 12.14 The Raid, Dean grabs a syringe of dead man's blood along with a machete from the Impala trunk.
  • In 14.03 The Scar, a vampire reveals that after being enhanced by Michael, they are now unaffected by dead man's blood. In addition, Jody Mills earlier states that she had Alex Jones test samples from the corpses of what turned out to be vampires with dead man's blood and it had no effect on them.
  • In 15.04 Atomic Monsters, when ambushing a vampire suspect, Sam hides a syringe of dead man's blood behind his back. However, they realize the girl is innocent as she has braces on her teeth, which a vampire couldn't have due to their fangs.
  • In 15.20 Carry On, Sam uses dead man's blood bullets to shoot a vampire in the leg and then in the head. While the headshot doesn't kill the vampire, it does knock him unconscious. When he wakes up and scoffs at the gun, Sam explains the significance of the bullets that he's using.

The Winchesters

In The Winchesters, dead man's blood has been used as follows:

  • In 1.09 Cast Your Fate to the Wind, while cornered by the leader of Il Soarta, John has his mother electrocute him to death, knowing that dead man's blood is the only way to weaken the vampire. Despite John having only been clinically dead for a matter of moments, his blood weakens the vampire to the point that Mary Campbell is able to kill him.