After Leviathan!Sam and Leviathan!Dean go on a killing spree (while driving a '67 Impala) causing the real Sam and Dean to become America's 2nd most wanted criminals, Frank Devereaux advises the boys to lock up the Impala to avoid detection. At first they drive a Pontiac Acadian, but after Dean and Sam's argument about Amy Pond, they part ways, and Dean steals a Dodge Challenger.
The car is a two door sport coup with mismatched panels (likely as a result of an accident) with North Carolina plates: S5I 2978. A first generation Dodge Challenger, it is a pony car built from 1970 to 1974 using the Chrysler E platform and sharing major components with the Plymouth Barracuda.
Dean is not impressed with the fuzzy black dice hanging from the rear-view mirror, or the pile of takeout wrappers on the passenger seat, but drives the car for longer than the Pontiac Acadian, even taking it from Las Vegas, Nevada, to Pike Creek, Delaware, when tracking down the newly married Sam and Becky. Castiel's trench coat is glimpsed in its trunk at one point.