Holy Oil

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Holy Oil is a rare substance. Castiel obtains some from Jerusalem, describing it as arid.5.03 Free To Be You And Me When the oil is ignited, its flames the celestial becomes trapped but can escape but most choose not too in fear of facing destruction.

Uses of Holy Oil

Castiel and Dean trap archangel Raphael inside a ring of burning holy oil, interrogating him for God's location. He responds, and claims that God is dead. They leave him in the still burning circle.5.03 Free To Be You And Me
Sam and Dean use it to trap the Trickster, forcing him to reveal that he is actually the Archangel Gabriel. Dean releases him by turning on the fire sprinklers
Lucifer uses it to trap Castiel, but he manages to break the circle and escape by throwing Meg on the flames. The extent of her injuries were unclear, but she survives
Castiel uses a molotov cocktail of Holy Oil to momentarily banish Michael
Dean traps the angel Balthazar in a circle of ignited Holy Oil and forces him to return the soul he got from a boy, Aaron Birch, in exchange for a piece of the Staff of Moses. Castiel causes the circle to vanish with a gesture when he wishes to free the angel