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Lilith
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* [[Sam Winchester]] (albeit with difficulty), once he has consumed vast amounts of [[demon blood]].<ref name="four22" />
* [[The First Blade]] (assumption based on the fact that it can kill any demon)
* Other demons - high level demons such as [[Cain]] and [[Alastair]] can probably harm her and Cain can probably kill her based on the fact that he has the [[Mark of Cain]] and has the ability of smiting
* The [[Four Hoursemen of the Apicalypse]] can most likely kill her considering one of them is [[Death]]
* Low ranking demons can kill her, but only if there are hundreds of them
* It's obvious that higher beings such as [[God]] and the [[Darkness]] can kill her
==Episodes==