|Location||Originally - Hell, since 2.22 - "the west" of the USA|
|Episode(s)||3.12 Jus in Bello|
Lilith is Sam's demonic rival.
The demon Lilith is one of the most infamous in demonology. Most importantly she's often depicted as Adam's first companion, or Satan's (Samael's) wife. In pagan religion she takes on a more peaceful role as The Goddess, the most important pagan entity.
The demon Tammi makes the first reference to her - though not by name - she tells Sam that a new leader has risen "in the west", and wants to kill him.
When Sam and Dean are caputred by the FBI and held at a local police station, they find themselves under siege by a horde of demons. When Ruby shows up to help, she explains that the demons are trying to kill Sam at Lilith's command. At the end of the episode Lilith shows up looking for Sam & Dean before destroying the sheriff's office and and killing everyone inside including Special Agent Victor Henriksen and Nancy Fitzgerald.