[[Castiel]] and [[Uriel]] ask Dean to torture [[Alastair]] to find out who is murdering angels. In the process, Alastair revels that it was Dean who broke the first seal of Lucifer's Cage.
[[Image:Mouth Of Cage.jpg|right|300px|thumb|The Mouth of [[Lucifer]]'s Cage begins to open.]]
===[[4.22 Lucifer Rising]]===
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[[Image:Mouth Of Cage.jpg|right|300px|thumb|The Mouth of [[Lucifer]]'s Cage begins to open.]]
Ruby helps Sam find a demon who can reveal [[Lilith]]'s location. In preparation for confronting Lilith, Ruby encourages Sam to drink the demon's blood (killing the woman it is possessing in the process). At [[St. Mary's Convent]], Sam uses his powers to kill Lilith, only to have Ruby reveal that Lilith is actually the final Seal holding the Cage secure. Lilith’s blood forms a spiral circle in the middle of the chapel at [[St. Mary's Convent]] and the gates of Lucifer’s prison open and Lucifer is released into the world.