Prayer

While prayer is used by those of religious faith, it is also used as a means of communication between humans, angels, and God. Nephilim can also receive prayer. Long before they knew of the existence of angel, Sam prayed everyday.

Episodes

4.18 The Monster at the End of This Book

Dean prays for Castiel's help when he is trying to stop Sam from meeting with Lilith.

5.18 Point of No Return

Looking to give himself to Michael as a vessel, Dean finds a preacher on the street and asks him to pray to the angels. Castiel hears this prayer and arrives, beating Dean in anger before taking him back to Bobby's.

6.03 The Third Man

Dean prays to Castiel telling him:

"Cas! Don't be a dick. We got ourselves a... plague-like situation down here, and... do you...do you copy?"

6.20 The Man Who Would Be King

Castiel prays to God for guidance, retelling his story of how he came to betray his friends in his war against Raphael.

7.01 Meet the New Boss

Castiel appears in response to Sam's prayer, when they want to try and get him to return all the souls to Purgatory.

9.01 I Think I'm Gonna Like It Here

Dean prays for any angel to help him, and many of the recent fallen angels answer his call, including Gadreel pretending to be Ezekiel.

9.09 Holy Terror

Castiel seeking aid, tries many variations of prayer in hopes that an angel will listen to him. He succeeds when the angel Muriel arrives at his motel room door.

11.02 Form and Void

After being infected by a rabid, Sam goes to a hospital chapel and prays to God for help.

"So... I know it's been a long time, but... Dean and I, we've -- we've been through a lot of bad. But this is different. This is my fault, and I don't know how to fix it. And if I have to die, I've made my peace with that, but... Please. Dean deserves better. Dean deserves a life. There are people out there, good people, who are going to suffer because of me, and I am not asking you to clean up my mess. Hell, I don't even know if you're out there, but... If you are... And if you can hear me, I, um... We need your help, God. We need to know there's hope. We need a sign."

13.01 Lost and Found

Angry over the loss of Castiel, Mary and even Crowley, Dean prays to God and demands that He bring them all back.

13.23 Let The Good Times Roll

When Apocalypse World Michael attacks Sam and Dean in the Bunker, Sam prays to Jack for help, who hears his prayer and saves them from Michael.