Smiting

Smiting is an ability inherent in all angels, allowing them to kill anything with a single touch. However, Alastair was able to deflect Castiel's attempts to smite him in 4.10 Heaven and Hell and due to Leviathans predating angels, they appeared to be immune as well.

The Host of Heaven is also able to combine their powers into one single focused blast of energy. Smiting of this magnitude has such power that it can cause fallout which will poison the areas for miles from ground zero. This fallout can negatively effect humans that approach ground zero, inducing a smiting sickness, which can lead to death (or in the case of Lot's wife, turn into a pillar of salt). Smiting of this magnitude rarely happens on Earth, with the destruction of Sodom and Gomorrah being the only known mass smiting before the arrival of Amara.