Smiting

Smiting is an ability inherent in all angels, allowing them to kill anything with a single touch. When angel places their hand on whom ever they wish to smite, the being face becomes consumed with light, leaving their eye-sockets burned out and liquefying their insides. However, Alastair was able to deflect Castiel's attempts to smite him in 4.10 Heaven and Hell and due to Leviathans predating angels, they appeared to be immune as well.

The Host of Heaven is also able to combine their powers into one single focused blast of energy. Smiting of this magnitude has such power that it can cause fallout which will poison the areas for miles from ground zero. This fallout can negatively effect humans that approach ground zero, inducing a smiting sickness, which can lead to death (or in the case of Lot's wife, turn into a pillar of salt). Smiting of this magnitude rarely happens on Earth, with the destruction of Sodom and Gomorrah being the only known mass smiting before the arrival of Amara.

Episodes

4.01 Lazarus Rising

While Sam is staking out Johnny Mac's Diner after Dean's earlier demon confrontation. Sam sneaks into the darkened diner, as he creeps in quietly, he sees the cook from earlier face-down on the floor, his hands bloody. Sam crouches and turns the man over, revealing his eyes burned out and drying blood caked on his cheeks. He soon gets tackled from behind by the demon waitress, they trade blows before Sam eventually shoves her away, reavealing that she too has empty, burned out eye sockets and blood trickling down her face.