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Borax , or sodium borate , is a compound found in most cleaning supplies and is a salt of boric acid. It's Its use as a weapon against the [[Leviathans]] came upon by happenstance when [[Sheriff Jody Mills]] spilled a bucket containing the cleaning solution -- Power Clean -- which dripped through the floor boards of [[Rufus's Cabin]] onto the Leviathan [[Chet]], causing an acidic reaction to in his body. The effect, however, is only temporary, but it can allow for enough time to get close enough and to decapitate the Leviathan. While weaker Leviathans appear to take longer to heal, the Leviathan leader, [[Dick Roman]], had shown showed higher resistance to borax, healing his burns near instantaneously after exposure, and treating it as more of a nuisance than hindrance.

As [[Bobby]] is testing out various methods to kill the [[Leviathan]] [[Chet]], frustrated that nothing appears to work, Chet begins mocking Bobby by telling him how he plans on eating him. As Bobby raises his machete to strike, several drops of a liquid fall from the ceiling onto Chet's arm and burn his skin, causing Chet to panic and plead for Bobby to get it off of him. The skin on Chet's arm turns yellow, then black, and black steam rises. Another drop falls and Chet's arm continues to burn, causing more pain. Another drop falls onto Chet's face is now also burning and a large patch on his arm is black, until at which point Bobby decapitates Chet once more. Bobby rushes upstairs to find the cause of the acidic effect on Chet, to find [[Jody Mills]], who had been scrubbing the floor and knocked over a bucket containing borax in the cleaning solution. With this information, Bobby places a call to [[Dean]] and informs instructs him to use anything with sodium borate -- any soaps or laundry powder with "borax" on the label.

Dean has [[Sheriff Osborne]] locate cleaning supplies with borax. In a fight with [[Leviathan!Sam]], Sheriff Osborne throws a bucket of borax onto the Leviathan, allowing Dean to decapitate it with a fire ax. Dean and the sheriff then rush to the interrogation room, where [[Leviathan!Dean]] is preparing to eat [[Sam]], when . Dean bursts into the room, flings liquid at the Leviathan , and cuts off his head with the ax.

After Bobby is captured by the Leviathans at [[Richard Roman Enterprises]], Sam and Dean stage a rescue that night, equipping themselves with pressure sprayers containing Power Clean. At a warehouse, [[Edgar]] and a truck driver are walking towards two men in suits who appear to be bodyguards. Dean and Sam enter and begin spray the bodyguards, Edgar , and the truck driver, whom who start to scream and writhe in pain as their skin burns.

[[Dick Roman]] soon becomes is alerted to Sam and Dean's arrival and leaves Bobby in his office while he goes to deal with them. Sam empties his pressure sprayer on Dick, who begins healing faster than the other Leviathans, casually wiping his face with a handkerchief. As he advances on Sam, Dean begins throwing more borax on Dick from behind, causing him to burn, marginally annoying him and allowing for Sam to slip past Dick and make his escape with Dean and Bobby.

When confronting [[Joyce Bicklebee]] and her assistant [[George]], in the ensuing fight, Joyce grabs Dean and throws him into a glass cabinet, while George throws Sam over a desk. As Sam tries to defend himself with punches, George grabs Sam around the throat and clues him to the bucket of borax next to them. He tells Sam to dunk his head into it before Joyce sees them talking. Joyce throws Dean onto a table, which breaks as Sam dunks George's head in the bucket. The sight of George's half burned off face, with exposed skull disgusts Joyce, who throws Dean into some glass doors. George alerts Sam to a sword in a display cabinet, and as Joyce advances on Dean, Sam is able to sneak behind her and decapitate Joyceher.

When [[Charlie Bradbury]] is given [[Frank Devereaux]]'s hard drive to hack, she finds a file on Leviathan's Leviathans and learns what borax will do to them. After witnessing the Leviathan [[Tarrell]] shapeshift and eat her superior, [[Pete]], Charlie flees to her apartment where she is met by Sam and Dean. To prove to her that they are not Leviathans, they pour borax onto their arms, assuages assuaging Charlie's fear when they do not begin to burn. Dean , in turn, pours borax on Charlie's hand to prove that she is human.

Learning that Dick is having a package delivered from a excavation site in Iran, and will have 42 minutes to intercept the package at the airport. , Sam, Dean , and Charlie formulate a plan, and . They successfully switch out the briefcase with one containing a bottle of Power Clean rigged with explosives, creating a borax bomb. When Dick receives the briefcase and opens it, his look of self-satisfaction quickly turns to confusion as the borax bomb counts down and explodes. The explosion causes a [the lower portion of [Victor!Leviathan|Victor]] to have the lower portion of his 's face to melt, leaving him lying prone on the floor, . Dick casually walks over him, with burns on his face , and orders the building locked down. With Charlie trapped in the building Pete begins stomping towardsher, but he is knocked down by Bobby who inadvertently sends him into Charlie, breaking her arm. Sam and Dean proceed to crash through the glass doors, and upon Charlie telling them Pete is a Leviathan, Dean throws a jar of borax into his face, causing him to collapse in pain.

While trying to get the blood of the [[Alpha Vampire]] for their weapon against Dick, Sam and Dean attempt to persuade the Alpha Vampire that the Leviathan's Leviathans are the ones poisoning the vampires. When news that Edgar has arrived to his residence arrives, Dean tells the Alpha Vampire that they will need soap or cleansers, anything with borax in it, only to have the Alpha Vampire order his children to lock Sam and Dean up in his study.

While speaking with Edgar, the Alpha Vampire questions him about the side effects of the Leviathan additive, which Edgar answers with indifference, telling him he wants the Alpha and his children to burn. Revealing He reveals that the additive kills [[werewolves]], [[shapeshifters]], anything with a taste for human flesh. Angry, the Alpha Vampire tells Edgar "they" come from "them" and that he is a son of Eve, all of which Edgar belittles as , saying that the other monsters being are nothing but mutts and that Eve was a whore. Edgar's insult to his mother provokes the Alpha to bare his fangs and lunge at Edgar, sending him into the wall. Grabbing a chilled bucket from the table, he splashes it onto Edgar, causes causing his flesh to burn from the borax. The effects are short, however, as Edgar is able to straighten up and attack the Alpha Vampire. As Edgar's face transforms, he is quickly decapitated by Sam.

With the plan to kill Dick set, Sam, Dean , and [[Castiel]] enlist the help of [[Meg]] to act as a distraction. Taking by crashing the [[Impala]], and crashing it into the front sign of Richard Rman Roman Enterprises. Meg exits the driver’s seat of the Impala with a bottle of Power Clean and machete in hand, as the Leviathan security guards begin opening fire. Meg begins retaliating, throwing Power Clean onto Leviathans and decapitating them.

Inside an RRE laboratory, Dick Roman samples the new additive -laced creamers as Castiel, holding a bottle of Power Clean, and Dean teleport into the room.

When [[Sam]] returns to [[Rufus's Cabin]] he is met by [[Dean]] , who pushes him to the floor and douses him with [[holy water]] and borax, much to Sam 's annoyance. When Sam refuses to do the same to Dean, Dean splashes himself with holy water and borax, to prove he isn't a [[demon]] or [[Leviathan]] either.